The first thing to map is what Artifactory is doing, not which repositories exist. A single instance usually blends hosted package storage, upstream proxy caching, virtual repository names, release promotion, build metadata, retention rules, and permission boundaries. Open source registries tend to cover the package protocols well while leaving promotion, cleanup, replication, or policy enforcement for you to arrange. The real decision is whether you need one universal front door for every ecosystem, or whether separate registries with consistent naming, authentication, and backup rules are acceptable.
If you want breadth from one tool, Nexus Repository is the closest analog: its Community Edition hosts Maven, npm, Docker, NuGet, PyPI, and many other formats behind a single manager. If your artifacts are mostly container images and Helm charts, Harbor is purpose-built for that path, adding role-based access through projects, policy-based replication between instances, vulnerability scanning, and image signing - the governance layer Artifactory bundles, focused on OCI content. For JavaScript shops, Verdaccio is a zero-config private npm registry that also proxies and caches npmjs.org, light enough to run beside a project without a separate database.
Migration happens repository by repository. Copy immutable artifacts first - through Artifactory exports, package-manager clients, or scripted API reads - then rebuild indexes in the target and repoint clients. Container images need tag and digest checks so a tag still resolves to the expected manifest; language packages need versions, checksums, and namespace ownership preserved. Virtual repositories become new endpoint conventions rather than a portable object, and build metadata rarely transfers cleanly, so decide whether you need it for audit or can rely on your CI system and deployment records instead.