MyPaint

MyPaint is a drawing and painting program for artists who want a simple workspace focused entirely on brushwork. Built around graphics tablets, it keeps the interface out of the way so you can concentrate on the canvas.

It offers an infinite canvas, a distraction-free fullscreen mode, and layered painting with layer groups and blend modes. The brushes are extremely configurable and driven by a realistic, paint-like pigment model, with a 15 bit Rec 709 linear RGB color space for smooth, accurate blending.

Brush settings can be saved per stroke, and pressure-sensitive tablets are supported throughout for natural, expressive strokes. MyPaint is free/libre/open source software that runs on Windows and Linux.